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Dimethyl succinate
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Catalog No. T5696Cas No. 106-65-0
Dimethyl succinate is found in nuts. Dimethyl succinate is present in roasted filberts. Dimethyl succinate is a flavouring ingredient.
Dimethyl succinate
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Purity: 96.94%
Catalog No. T5696Cas No. 106-65-0
Dimethyl succinate is found in nuts. Dimethyl succinate is present in roasted filberts. Dimethyl succinate is a flavouring ingredient.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $40 | In Stock | In Stock | |
| 1 g | $56 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.94%
Appearance:Liquid
Color:Transparent
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Product Introduction
Dimethyl succinate AI Summary
Dimethyl succinate exhibits multiple bioactivities, including functioning as an agonist of the Thyroid Stimulating Hormone Receptor and an activator of intracellular cAMP concentrations. It acts as an inhibitor of Polymerase Iota and induces DNA re-replication in both normal breast cells and colon adenocarcinoma cells. Additionally, Dimethyl succinate serves as an antagonist of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. Its potencies in these various bioassays range from 145.8 nM to 70794.6 nM. Moreover, Dimethyl succinate inhibits TET in human THP-1 cells, leading to a reduction in 5hmc/5mc levels in a dose-dependent manner with 15.0% inhibition observed at a 100 µM concentration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dimethyl succinate is found in nuts. Dimethyl succinate is present in roasted filberts. Dimethyl succinate is a flavouring ingredient. |
| Molecular Weight | 146.14 |
| Formula | C6H10O4 |
| Cas No. | 106-65-0 |
| Smiles | COC(=O)CCC(=O)OC |
| Relative Density. | 1.117 g/cm3 at 25℃ (lit.) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (1710.69 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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